Clear cell adenocarcinoma of the vagina and cervix

Clear cell adenocarcinoma of the vagina and cervix. An update of the central Netherlands registry showing twin age incidence peaks.

BACKGROUND The objective of this study was to update the registry of women in the Netherlands with clear cell adenocarcinoma (CCAC) of the cervix or vagina with or without intrauterine exposure to diethylstilbestrol (DES). METHODS From a nationwide search in PALGA, the automated pathology registry in the Netherlands, data were gathered on women with CCAC born after 1947. Information obtained ...

LBC Diagnosis of Clear Cell Adenocarcinoma of Vagina: An Interesting Case Report

Clear cell Adenocarcinoma (CCA) of vagina is a rare malignancy, reported at early ages in daughters of mothers exposed to diethylstilbestrol (DES) in utero. Histological features are well established, however cytological findings and moreover Liquid Based Cytology (LBC) morphology is not well characterized. We report a case of primary vaginal CCA first time picked up on LBC smear examination, c...

Clear cell adenocarcinoma of vagina associated with uterine prolapse: A rare entity

Introduction: Clear cell adenocarcinoma usually affects the cells of the female genital tract. In this cancer, cells become vacuolated and filled with glycogen hence it is called clear cell. This cancer is insidious and slow growing. Here we report a case of uterine prolapse with polypoidal growth in the vagina which on histopathological examination was diagnosed as a case of clear cell adenoca...

Atresia of the Vagina and Cervix Uteri

Non-Diethylstilbestrol-Associated Primary Clear Cell Carcinoma of the Vagina: Two Case Reports with Immunohistochemical Studies and Literature Review

Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-...